FDA-approved antidepressants are often prescribed drugs that are used to treat anxiety, depression, and other mental health conditions. Antidepressants can be useful in treating certain illnesses, but they can also have a number of negative side effects, such as weight loss. I'll explain what antidepressants are, how they affect weight, and which antidepressants are known to contribute to weight gain or reduction in this post. Lastly, I will discuss whether antidepressant prescriptions have ever been given with the express purpose of helping someone lose weight and whether it is safe to avoid antidepressant-induced weight loss.
Antidepressant That Causes Weight Loss
While most antidepressants are associated with weight gain, a few have been shown to cause weight loss in some people. These include:
- Bupropion (Wellbutrin): Bupropion is a norepinephrine and dopamine reuptake inhibitor (NDRI), which means it works by blocking the reuptake of these neurotransmitters in the brain. This can increase the levels of norepinephrine and dopamine, which can lead to increased energy levels, improved mood, and decreased appetite.
- Fluoxetine (Prozac): Fluoxetine is a selective serotonin reuptake inhibitor (SSRI), which means it works by increasing the levels of serotonin in the brain. Serotonin is a neurotransmitter that plays a role in mood regulation, appetite, and sleep. Fluoxetine has been shown to cause weight loss in some people, but this effect is usually temporary.
- Duloxetine (Cymbalta): Duloxetine is a serotonin-norepinephrine reuptake inhibitor (SNRI), which means it works by increasing the levels of both serotonin and norepinephrine in the brain. Duloxetine has been shown to cause weight loss in some people, but this effect is also usually temporary.
It is important to note that not everyone who takes these antidepressants will experience weight loss. In fact, some people may actually gain weight. The effects of antidepressants on weight can vary depending on the individual and the specific medication.

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